Neurologic & Orthopedic Hospital Blog — Drs. Cerullo, Sheinkop & Gleiber, Chicago

Glioblastoma Survivors

Senator Ted Kennedy’s shocking news gives us all pause. Even though I deal with news like his on a daily basis, the enormity of the national response has caused me to reflect on the less appreciated facts of his case. While glioblastoma (GBM) carries a terrible statistical prognosis, especially in older people, it is not a death sentence. Remember that statistics never apply to the individual. I, as most neurosurgeons, have patients who are living long after the diagnosis of glioblastoma was established. So why are these patients (survivors) different? Recent research at the molecular/genetic level indicates that there are many different types of GBM, each with different genetic abnormalities responsible for their growth characteristics. Age certainly plays a role, with younger people generally doing better than older. The location of the tumor may be important, especially in terms of the extent of surgical removal (reduction of tumor burden) possible. New chemotherapeutic and radiotherapeutic possibilities are proving helpful if not in “curing” them, at least prolonging meaningful life. Then there are the “intangibles”, which I personally feel make a difference. These include the attitude of the patient towards his/her disease. The aggressive fighter will fare better than the passive victim. Those with strong support systems, family and faith, will venture farther along the less proven paths. “Non traditional” treatment including acupuncture, meditation and nutrition may ultimately prove their value. All in all, glioblastoma is not a death sentence. It is a call to action.

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